一、团队简介

特种动物病原与免疫科技创新团队，以特种动物病原与免疫为研究重点，立足于解决困扰我国特种动物产业发展多年的疫病防控问题，系统性的研究特种动物病原学和免疫学。近年来，该团队深入开展特种动物病原学、免疫学的研究，彻底摸清特种动物重要病原的生态学分布，流行特征和传播特点，从系统生态学的角度研究特种动物疾病在时空中发生、发展的规律和控制方法，为特种动物疫病防控奠定坚实的基础。为维护毛皮动物养殖业的稳定，保障该产业的健康有序发展提供重要的技术支撑。

该团队在病原学方面着重开展了特种动物犬瘟热病毒、水貂肠炎细小病毒、狂犬病病毒、水貂阿留申病毒、鹿布氏杆菌和水貂星状病毒等重要病原体的遗传多样性和新型诊断技术研究；在免疫学方面开展了特种动物基因重组疫苗，重要病原体单克隆抗体，病毒B细胞抗原表位，新型表位疫苗等免疫技术及机理研究。

目前，该团队固定人员12名，流动研究生10名。承担国家863计划、农业科技行业专项、国家自然科学基金、吉林省重大科技攻关、吉林省自然基金项目等30余项，到位经费1000余万元。获得吉林省科技进步一等奖1项、长春市科技进步特等奖1项，吉林市科技进步特等奖1项，参加获得国家科技进步一等奖1项，中国农业科学院一等奖1项、吉林省科技进步二等奖2项，出版学术专著3部。近年来，以第一完成单位发表文章75篇（其中sci收录论文30篇），获得授权发明专利3项。

二、团队主要代表性论文、论著

（一）sci收录：

1.Wen, Y., Wang, H., Wu, H., Yang, F., Tripp, R.A., Hogan, R.J., Fu, Z.F. Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination[J]. Journal of virology, 2011, 85(4): 1634-1644.

2.Yi L, Tong M, Cheng Y, Song W, Cheng S. Phylogenetic Analysis of Canine Parvovirus VP2 Gene in China. Transbound Emerg Dis. Transbound Emerg Dis. 2014 Sep 11. doi: 10.1111/tbed.12268.

3. Feng-Xue Wang., Wen, Y., Yang B., Liu, Z., Shi, X.C., Leng X., Song, N., Wu, H., Chen, L.-Z., Cheng, S.-P. Role of non-structural protein 2 in the regulation of the replication of the porcine reproductive and respiratory syndrome virus in MARC-145 cells: effect of gene silencing and over expression[J]. Vet. Microbiol., 2012a, 161:58-65.

4.Zhu, H., Chen, X., Shao, X., Ba, H., Wang, F., Wang, H., Yang, Y., Sun, N., Ren, J., Cheng, S., Wen, Y. Characterization of a virulent dog-originated rabies virus affecting more than twenty fallow deer (Dama dama) in Inner Mongolia, China[J]. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2015, 31(127-134.

5.Wang J, Cheng Y, Zhang M, Zhao H, Lin P, Yi L, Tong M, Cheng S: Development of a nanoparticle-assisted PCR (nanoPCR) assay for detection of mink enteritis virus (MEV) and genetic characterization of the NS1 gene in four Chinese MEV strains. BMC Vet Res 2015, 11(1):1.

6.Zhang, Shu-Qin，Tan, Bin，Guo, Li，Wang, Feng-Xue，Zhu, Hong-Wei，Wen, Yong-Jun，Cheng, Shipeng(*)，Genetic diversity of bovine viral diarrhea viruses in commercial bovine serum batches of Chinese origin，Infection, Genetics and Evolution，2014，27：230-233

7.Na Sun, Yong Yang, Gui-Sheng Wang, Xi-Qun Shao, Shu-Qin Zhang, Feng-Xue Wang, Bin Tan, Fu-Lin Tian, Shi-Peng Cheng, Yong-Jun Wen. Detection and Characterization of Avastrovirus Associated with Diarrhea Isolated from Minks in China. Food and Environ Virol, 2014(6):169-174.

8.Wang, F.X., Zhang, S.Q., Zhu, H.W., Yang, Y., Sun, N., Tan, B., Li, Z.G., Cheng, S.P., Fu, Z.F., Wen, Y.J. Recombinant rabies virus expressing the H protein of canine distemper virus protects dogs from the lethal distemper challenge[J]. Vet Microbiol, 2014, 174(3-4): 362-371.

9.Wang, F., Yan, X., Chai, X., Zhang, H., Zhao, J., Wen, Y., Wu, W. Differentiation of canine distemper virus isolates in fur animals from various vaccine strains by reverse transcription-polymerase chain reaction-restriction fragment length polymorphism according to phylogenetic relations in china[J]. Virology journal, 2011, 8：85.

10.Wang J, Cheng S, Yi L, Cheng Y, Yang S, Xu H, Zhao H, Yan X, Wu H: Evidence for natural recombination between mink enteritis virus and canine parvovirus. Virology journal 2012, 9(1):252.

11.Zhang S.，Tan B.，Ding Y.，Wang F.，Guo L.，Wen Y.，Cheng S.(*)，Wu H.，Complete genome sequence and pathogenesis of bovine viral diarrhea virus JL-1 isolate from cattle in China，Virology Journal， 2014 Apr 8;11: 67

12.Bin Tan, Yong-Jun Wen, Feng-Xue Wang , Shu-Qin Zhang, Xiu-Dong Wang, Jia-Xin Hu, Shi-Peng Cheng and Hua Wu* Pathogenesis and Phylogenetic Analyses of Canine Distemper Virus Strain ZJ7 Isolate from Domestic Dogs in China. Virology Journal. 8:520.2011

13.Yi L, Cheng S, Xu H, Wang J, Cheng Y, Yang S, Luo B.Development of a combined canine distemper virus specific RT-PCR protocol for the differentiation of infected and vaccinated animals (DIVA) and genetic characterization of the hemagglutinin gene of seven Chinese strains demonstrated in dogs, J. Virol. Methods , 2012.

14.Xue Leng, Zhenguang Li , Mingqi Xia , Xiyu Li , Fengxue Wang, Wei Wang,Xiuhua Zhang, Hua Wu. Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation. Vet. Microbiol. 2012,157:50–60

15.Zhenguang Li, Xue Leng, Qiaoling Qi, Fengxue Wang, Yongjun Wen, Bin Tan, Yanliang He, Mingqi Xia, Wei Lu, Lizhi Chen,Shipeng Cheng, Hua Wu. Complete Genome Sequence of a Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus NM1 Strain from Northern China. J.Virol. 2012,86(24):13863-13864

三、主要科技奖励

四、获得授权的发明专利

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